منابع مشابه
Cell migration during morphogenesis.
During development, functional structures must form with the correct three-dimensional geometry composed of the correct cell types. In many cases cell types are specified at locations distant to where they will ultimately reside for normal biological function. Although cell migration is crucial for normal development and morphogenesis of animal body plans and organ systems, abnormal cell migrat...
متن کاملESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death.
In eukaryotic cells, the nuclear envelope separates the genomic DNA from the cytoplasmic space and regulates protein trafficking between the two compartments. This barrier is only transiently dissolved during mitosis. Here, we found that it also opened at high frequency in migrating mammalian cells during interphase, which allowed nuclear proteins to leak out and cytoplasmic proteins to leak in...
متن کاملNuclear envelope in nuclear positioning and cell migration.
Hauling and anchoring the nucleus within immobile or motile cells, tissues, and/or syncytia represents a major challenge. In the past 15 years, Linkers of the Nucleoskeleton to the Cytoskeleton (LINC complexes) have emerged as evolutionary-conserved molecular devices that span the nuclear envelope and provide interacting interfaces for cytoskeletal networks and molecular motors to the nuclear e...
متن کاملCell mechanics control rapid transitions between blebs and lamellipodia during migration.
Protrusion formation is an essential step during cell migration. Cells migrating in three-dimensional environments and in vivo can form a wide variety of protrusion types, including actin polymerization-driven lamellipodia, and contractility-driven blebs. The ability to switch between different protrusions has been proposed to facilitate motility in complex environments and to promote cancer di...
متن کاملA computational mechanics approach to assess the link between cell morphology and forces during confined migration.
Confined migration plays a fundamental role during several biological phenomena such as embryogenesis, immunity and tumorogenesis. Here, we propose a two-dimensional mechanical model to simulate the migration of a HeLa cell through a micro-channel. As in our previous works, the cell is modelled as a continuum and a standard Maxwell model is used to describe the mechanical behaviour of both the ...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2011
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2010.10.015